A Comprehensive Review of the Pharmacodynamics, Pharmacokinetics, and Clinical Effects of the Neutral Endopeptidase Inhibitor Racecadotril

Racecadotril, via its active metabolite thiorphan, is an inhibitor of the enzyme neutral endopeptidase (NEP, EC 3.4.24.11), thereby increasing exposure to NEP substrates including enkephalins and atrial natriuretic peptide (ANP). Upon oral administration racecadotril is rapidly and effectively conve...

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Bibliografiske detaljer
Main Authors: Eberlin, Marion, Mück, Tobias, Michel, Martin C.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Research Foundation 2012
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3362754/
https://ncbi.nlm.nih.gov/pubmed/22661949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2012.00093
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