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Overexpression of SARAF Ameliorates Pressure Overload–Induced Cardiac Hypertrophy Through Suppressing STIM1-Orai1 in Mice

Background/Aims: Activation of stromal interaction molecule 1 (STIM1) and Orai1 participates in the development of cardiac hypertrophy. Store-operated Ca2+ entry-associated regulatory factor (SARAF) is an intrinsic inhibitor of STIM1-Orai1 interaction. Thus, we hypothesized that SARAF could prevent...

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Detalhes bibliográficos
Main Authors: Fengdan Dai, Yan Zhang, Qiang Wang, De Li, Yongjian Yang, Shuangtao Ma, Dachun Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Colecção:Cellular Physiology and Biochemistry
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Acesso em linha:https://www.karger.com/Article/FullText/490036
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