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Harmful Roles of TLR3 and TLR9 in Cardiac Dysfunction Developing during Polymicrobial Sepsis

We determined the roles of TLR3 and TLR9 in adverse events of polymicrobial sepsis, with a focus on development of septic cardiomyopathy, progression of which we have recently shown to be complement- and histones-dependent. So Wt, TLR3-knocked out (K.O.), and TLR9-K.O. mice were subjected to polymic...

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Main Authors: Fatemeh Fattahi, Mark W. Russell, Elizabeth A. Malan, Michella Parlett, Elizabeth Abe, Firas S. Zetoune, Peter A. Ward
Formáid: Artigo
Teanga:Inglês
Foilsithe: Hindawi Limited 2018-01-01
Sraith:BioMed Research International
Rochtain Ar Líne:http://dx.doi.org/10.1155/2018/4302726
Clibeanna: Cuir Clib Leis
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