ALPHLARD: a Bayesian method for analyzing HLA genes from whole genome sequence data

Abstract Background Although human leukocyte antigen (HLA) genotyping based on amplicon, whole exome sequence (WES), and RNA sequence data has been achieved in recent years, accurate genotyping from whole genome sequence (WGS) data remains a challenge due to the low depth. Furthermore, there is no m...

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Main Authors: Shuto Hayashi, Rui Yamaguchi, Shinichi Mizuno, Mitsuhiro Komura, Satoru Miyano, Hidewaki Nakagawa, Seiya Imoto
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2018-11-01
Serier:BMC Genomics
Fag:
HLA genotyping
Next generation sequencing
Whole genome sequencing
Whole exome sequencing
Cancer immunogenomics
Bayesian hierarchical model
Online adgang:http://link.springer.com/article/10.1186/s12864-018-5169-9
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