ALPHLARD: a Bayesian method for analyzing HLA genes from whole genome sequence data

Abstract Background Although human leukocyte antigen (HLA) genotyping based on amplicon, whole exome sequence (WES), and RNA sequence data has been achieved in recent years, accurate genotyping from whole genome sequence (WGS) data remains a challenge due to the low depth. Furthermore, there is no m...

詳細記述

保存先:
書誌詳細
主要な著者: Shuto Hayashi, Rui Yamaguchi, Shinichi Mizuno, Mitsuhiro Komura, Satoru Miyano, Hidewaki Nakagawa, Seiya Imoto
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2018-11-01
シリーズ:BMC Genomics
主題:
HLA genotyping
Next generation sequencing
Whole genome sequencing
Whole exome sequencing
Cancer immunogenomics
Bayesian hierarchical model
オンライン･アクセス:http://link.springer.com/article/10.1186/s12864-018-5169-9
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