Cinchona Alkaloid Derivative-Catalyzed Enantioselective Synthesis via a Mannich-Type Reaction and Antifungal Activity of β-Amino Esters Bearing Benzoheterocycle Moieties

An efficient synthesis of highly functionalized chiral β-amino ester derivatives containing benzothiophene and benzothiazole moieties is developed by a Mannich-type reaction using a cinchona alkaloid-derived thiourea catalyst. The desired products were obtained in good yields and high enantioselecti...

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Main Authors: Han Xiao, Fang Wu, Li Shi, Zhiwei Chen, Shihu Su, Chenghao Tang, Hongtao Wang, Zhining Li, Meichuan Li, Qingcai Shi
Formáid: Artigo
Teanga:Inglês
Foilsithe: MDPI AG 2014-04-01
Sraith:Molecules
Ábhair:
β-amino acid ester
antifungal activity
benzoheterocycle
enantioselective synthesis
Rochtain Ar Líne:http://www.mdpi.com/1420-3049/19/4/3955
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