Cholinergic Abnormalities, Endosomal Alterations and Up-Regulation of Nerve Growth Factor Signaling in Niemann-Pick Type C Disease

<p>Abstract</p> <p>Background</p> <p>Neurotrophins and their receptors regulate several aspects of the developing and mature nervous system, including neuronal morphology and survival. Neurotrophin receptors are active in signaling endosomes, which are organelles that p...

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Detalhes bibliográficos
Main Authors: Cabeza Carolina, Figueroa Alicia, Lazo Oscar M, Galleguillos Carolina, Pissani Claudia, Klein Andrés, Gonzalez-Billault Christian, Inestrosa Nibaldo C, Alvarez Alejandra R, Zanlungo Silvana, Bronfman Francisca C
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2012-03-01
Colecção:Molecular Neurodegeneration
Assuntos:
NGF
Endosomes
Cholesterol
Niemann-Pick type C1
cholinergic system
PC12
Acesso em linha:http://www.molecularneurodegeneration.com/content/7/1/11
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