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Clinical and genetic determinants of warfarin pharmacokinetics and pharmacodynamics during treatment initiation.

Variable warfarin response during treatment initiation poses a significant challenge to providing optimal anticoagulation therapy. We investigated the determinants of initial warfarin response in a cohort of 167 patients. During the first nine days of treatment with pharmacogenetics-guided dosing, S...

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Detalhes bibliográficos
Main Authors: Inna Y Gong, Ute I Schwarz, Natalie Crown, George K Dresser, Alejandro Lazo-Langner, GuangYong Zou, Dan M Roden, C Michael Stein, Marc Rodger, Philip S Wells, Richard B Kim, Rommel G Tirona
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3218053?pdf=render
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