Regulation of the ER Stress Response by the Ion Channel Activity of the Infectious Bronchitis Coronavirus Envelope Protein Modulates Virion Release, Apoptosis, Viral Fitness, and Pathogenesis

Coronavirus (CoV) envelope (E) protein is a small structural protein critical for virion morphogenesis and release. The recently characterized E protein ion channel activity (EIC) has also been implicated in modulating viral pathogenesis. In this study, we used infectious bronchitis coronavirus (IBV...

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Main Authors: Shumin Li, Lixia Yuan, Guo Dai, Rui Ai Chen, Ding Xiang Liu, To Sing Fung
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-01-01
Colecção:Frontiers in Microbiology
Assuntos:
coronavirus
viroporin
ion channel activity
ER stress response
pro-inflammatory cytokine
pathogenesis
Acesso em linha:https://www.frontiersin.org/article/10.3389/fmicb.2019.03022/full
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