Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2

Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). Here, we deliberately exploit non-neutralizing RBD antibodies, showing they can dramatically assist...

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Библиографические подробности
Главные авторы: Shion A. Lim, Josef A. Gramespacher, Katarina Pance, Nicholas J. Rettko, Paige Solomon, Jing Jin, Irene Lui, Susanna K. Elledge, Jia Liu, Colton J. Bracken, Graham Simmons, Xin X. Zhou, Kevin K. Leung, James A. Wells
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis Group 2021-01-01
Серии:mAbs
Предметы:
Bispecific
neutralizing antibody
knob-in-hole
COVID-19
SARS-CoV-2
Online-ссылка:https://www.tandfonline.com/doi/10.1080/19420862.2021.1893426
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