Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2

Numerous neutralizing antibodies that target SARS-CoV-2 have been reported, and most directly block binding of the viral Spike receptor-binding domain (RBD) to angiotensin-converting enzyme II (ACE2). Here, we deliberately exploit non-neutralizing RBD antibodies, showing they can dramatically assist...

詳細記述

保存先:
書誌詳細
主要な著者: Shion A. Lim, Josef A. Gramespacher, Katarina Pance, Nicholas J. Rettko, Paige Solomon, Jing Jin, Irene Lui, Susanna K. Elledge, Jia Liu, Colton J. Bracken, Graham Simmons, Xin X. Zhou, Kevin K. Leung, James A. Wells
フォーマット: Artigo
言語:Inglês
出版事項: Taylor & Francis Group 2021-01-01
シリーズ:mAbs
主題:
Bispecific
neutralizing antibody
knob-in-hole
COVID-19
SARS-CoV-2
オンライン･アクセス:https://www.tandfonline.com/doi/10.1080/19420862.2021.1893426
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