Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1

Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic metabolism. This study aimed to find potent and selective inhibitors against hCE1 from phytochemicals and their derivatives. To t...

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Main Authors: Li-Wei Zou, Tong-Yi Dou, Ping Wang, Wei Lei, Zi-Miao Weng, Jie Hou, Dan-Dan Wang, Yi-Ming Fan, Wei-Dong Zhang, Guang-Bo Ge, Ling Yang
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2017-06-01
Serija:Frontiers in Pharmacology
Teme:
human carboxylesterase 1 (hCE1)
ursolic acid
oleanolic acid
structure-activity relationship (SAR)
selective inhibitors
Online dostop:http://journal.frontiersin.org/article/10.3389/fphar.2017.00435/full
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