Structure-Activity Relationships of Pentacyclic Triterpenoids as Potent and Selective Inhibitors against Human Carboxylesterase 1

Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic metabolism. This study aimed to find potent and selective inhibitors against hCE1 from phytochemicals and their derivatives. To t...

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Main Authors: Li-Wei Zou, Tong-Yi Dou, Ping Wang, Wei Lei, Zi-Miao Weng, Jie Hou, Dan-Dan Wang, Yi-Ming Fan, Wei-Dong Zhang, Guang-Bo Ge, Ling Yang
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-06-01
Colecção:Frontiers in Pharmacology
Assuntos:
human carboxylesterase 1 (hCE1)
ursolic acid
oleanolic acid
structure-activity relationship (SAR)
selective inhibitors
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fphar.2017.00435/full
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