Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors

Abstract Background Genetic variants in the subunits of the gamma-aminobutyric acid type A (GABAA) receptors are implicated in the onset of multiple pathologic conditions including genetic epilepsy. Previous work showed that pathogenic GABAA subunits promote misfolding and inefficient assembly of th...

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Main Authors: Meng Wang, Edmund Cotter, Ya-Juan Wang, Xu Fu, Angela L. Whittsette, Joseph W. Lynch, R. Luke Wiseman, Jeffery W. Kelly, Angelo Keramidas, Ting-Wei Mu
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-04-01
Colecção:Cell & Bioscience
Acesso em linha:https://doi.org/10.1186/s13578-022-00783-w
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