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The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta

The human adaptive immune response enables the targeting of epitopes on pathogens with high specificity. Infection with a pathogen induces somatic hyper-mutation and B-cell selection processes that govern the shape and diversity of the antibody sequence landscape. To date, even the largest immunome...

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Bibliografski detalji
Glavni autori: Samuel Schmitz, Emily A. Schmitz, James E. Crowe, Jens Meiler
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis Group 2022-12-01
Serija:mAbs
Teme:
Online pristup:https://www.tandfonline.com/doi/10.1080/19420862.2022.2068212
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