PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment

Abstract Chemokines are highly expressed in tumor microenvironment and play a critical role in all aspects of tumorigenesis, including the recruitment of tumor-promoting immune cells, activation of cancer-associated fibroblasts, angiogenesis, metastasis, and growth. Poly (ADP-ribose) polymerase (PAR...

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Detalhes bibliográficos
Main Authors: Sarah Johnson, Yaroslava Karpova, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov, Alexei V. Tulin
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-05-01
Colecção:BMC Cancer
Assuntos:
PARP
PARG
Poly(ADP-ribose) glycohydrolase
Poly(ADP-ribose) polymerase
Poly(ADP-ribose), chemokines
Tumorigenesis
Acesso em linha:https://doi.org/10.1186/s12885-022-09651-9
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