Arginase: An emerging and promising therapeutic target for cancer treatment

Arginase is a key hydrolase in the urea cycle that hydrolyses L-arginine to urea and L-ornithine. Increasing number of studies in recent years demonstrate that two mammalian arginase isoforms, arginase 1 (ARG1) and arginase 2 (ARG2), were aberrantly upregulated in various types of cancers, and playe...

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Bibliografische gegevens
Hoofdauteurs: Fanglin Niu, Yi Yu, Zhuozhuo Li, Yuanyuan Ren, Zi Li, Qiang Ye, Ping Liu, Chenshuang Ji, Lu Qian, Yuyan Xiong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2022-05-01
Reeks:Biomedicine & Pharmacotherapy
Onderwerpen:
Arginase
Cancer
Mechanism
L-arginine
Inhibitors
Therapeutic target
Online toegang:http://www.sciencedirect.com/science/article/pii/S0753332222002281
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