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AKT inhibitors promote cell death in cervical cancer through disruption of mTOR signaling and glucose uptake.

PI3K/AKT pathway alterations are associated with incomplete response to chemoradiation in human cervical cancer. This study was performed to test for mutations in the PI3K pathway and to evaluate the effects of AKT inhibitors on glucose uptake and cell viability.Mutational analysis of DNA from 140 p...

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Detalhes bibliográficos
Main Authors: Ramachandran Rashmi, Carl DeSelm, Cynthia Helms, Anne Bowcock, Buck E Rogers, Janet L Rader, Perry W Grigsby, Julie K Schwarz
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2014-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3976291?pdf=render
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