Phenotype selection reveals coevolution of muscle glycogen and protein and PTEN as a gate keeper for the accretion of muscle mass in adult female mice.

We have investigated molecular mechanisms for muscle mass accretion in a non-inbred mouse model (DU6P mice) characterized by extreme muscle mass. This extreme muscle mass was developed during 138 generations of phenotype selection for high protein content. Due to the repeated trait selection a compl...

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Main Authors: Mandy Sawitzky, Anja Zeissler, Martina Langhammer, Maximilian Bielohuby, Peggy Stock, Harald M Hammon, Solvig Görs, Cornelia C Metges, Barbara J M Stoehr, Martin Bidlingmaier, Carolin Fromm-Dornieden, Bernhard G Baumgartner, Bruno Christ, Bertram Brenig, Gerhard Binder, Friedrich Metzger, Ulla Renne, Andreas Hoeflich
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2012-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3387210?pdf=render
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