Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance

Anti-apoptotic BCL-2 family members bind to BH3-only proteins and multidomain BAX/BAK to preserve mitochondrial integrity and maintain survival. Whereas inhibition of these interactions is the biological basis of BH3-mimetic anti-cancer therapy, the actual response of membrane-bound protein complexe...

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Main Authors: Jessie Pécot, Laurent Maillet, Janic Le Pen, Céline Vuillier, Sophie de Carné Trécesson, Aurélie Fétiveau, Kristopher A. Sarosiek, Florian J. Bock, Frédérique Braun, Anthony Letai, Stephen W.G. Tait, Fabien Gautier, Philippe P. Juin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2016-12-01
Sraith:Cell Reports
Ábhair:
BCL-xL
membrane localization
BH3 mimetic resistance
Rochtain Ar Líne:http://www.sciencedirect.com/science/article/pii/S2211124716316382
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