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Direct Comparison of Mononucleated and Binucleated Cardiomyocytes Reveals Molecular Mechanisms Underlying Distinct Proliferative Competencies

Summary: The mammalian heart is incapable of regenerating a sufficient number of cardiomyocytes to ameliorate the loss of contractile muscle after acute myocardial injury. Several reports have demonstrated that mononucleated cardiomyocytes are more responsive than are binucleated cardiomyocytes to p...

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Detalhes bibliográficos
Main Authors: Rebecca Windmueller, John P. Leach, Apoorva Babu, Su Zhou, Michael P. Morley, Aoi Wakabayashi, Nataliya B. Petrenko, Patrick Viatour, Edward E. Morrisey
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-03-01
Colecção:Cell Reports
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124720301959
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