Efficient Synthesis of Pyrazinoic Acid Hybrid Conjugates

Abstract Benzotriazole-activated pyrazinoic acid was utilized as a versatile building block for the efficient and convenient synthesis of novel hybrid conjugates of pyrazinoic acid with secondary amines via amino acid linkers in high yields.

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Autori principali: Siva S. Panda, Abdullah M. Asiri, Mohamed Elagawany, Devan D. Buchanan, Behrad Torkian, Keerthana Bathala, Sean J. Thomas, Jason E. Capito, Muhammad N. Arshad, Abeer N. Al-Romaizan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Georg Thieme Verlag KG 2017-03-01
Serie:SynOpen
Soggetti:
pyrazinamide
pyrazinoic acid
secondary amines
amino acids
benzotriazole methodology
antituberculosis
Accesso online:http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1590800
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