NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency

μ-Conotoxins are potent and highly specific peptide blockers of voltage-gated sodium channels. In this study, the solution structure of μ-conotoxin GIIIC was determined using 2D NMR spectroscopy and simulated annealing calculations. Despite high sequence similarity, GIIIC adopts a thre...

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Main Authors: Peta J. Harvey, Nyoman D. Kurniawan, Rocio K. Finol-Urdaneta, Jeffrey R. McArthur, Dorien Van Lysebetten, Thomas S. Dash, Justine M. Hill, David J. Adams, Thomas Durek, David J. Craik
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2018-10-01
Series:Molecules
Assuntos:
μ-conotoxins
voltage-gated sodium channel blocker
NMR
protein structure
Acceso en liña:http://www.mdpi.com/1420-3049/23/10/2715
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