Neutralizing Antibodies Against Factor VIII Can Occur Through a Non-Germinal Center Pathway

Humoral immunity to factor VIII (FVIII) represents a significant challenge for the treatment of patients with hemophilia A. Current paradigms indicate that neutralizing antibodies against FVIII (inhibitors) occur through a classical CD4 T cell, germinal center (GC) dependent process. However, clinic...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Seema R. Patel, Taran S. Lundgren, Wallace Hunter Baldwin, Courtney Cox, Ernest T. Parker, John F. Healey, Ryan P. Jajosky, Patricia E. Zerra, Cassandra D. Josephson, Christopher B. Doering, Sean R. Stowell, Shannon L. Meeks
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Frontiers Media S.A. 2022-05-01
श्रृंखला:Frontiers in Immunology
विषय:
hemophilia A
germinal center
B cells
neutralizing antibodies (inhibitors)
extrafollicular pathway
ऑनलाइन पहुंच:https://www.frontiersin.org/articles/10.3389/fimmu.2022.880829/full
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