Neutralizing Antibodies Against Factor VIII Can Occur Through a Non-Germinal Center Pathway

Humoral immunity to factor VIII (FVIII) represents a significant challenge for the treatment of patients with hemophilia A. Current paradigms indicate that neutralizing antibodies against FVIII (inhibitors) occur through a classical CD4 T cell, germinal center (GC) dependent process. However, clinic...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Seema R. Patel, Taran S. Lundgren, Wallace Hunter Baldwin, Courtney Cox, Ernest T. Parker, John F. Healey, Ryan P. Jajosky, Patricia E. Zerra, Cassandra D. Josephson, Christopher B. Doering, Sean R. Stowell, Shannon L. Meeks
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2022-05-01
Cyfres:Frontiers in Immunology
Pynciau:
hemophilia A
germinal center
B cells
neutralizing antibodies (inhibitors)
extrafollicular pathway
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fimmu.2022.880829/full
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