Salsalate, but not metformin or canagliflozin, slows kidney cyst growth in an adult-onset mouse model of polycystic kidney diseaseResearch in context

Background: Multiple preclinical studies have highlighted AMP-activated protein kinase (AMPK) as a potential therapeutic target for autosomal dominant polycystic kidney disease (ADPKD). Both metformin and canagliflozin indirectly activate AMPK by inhibiting mitochondrial function, while salsalate is...

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Egile Nagusiak: Wouter N. Leonhard, Xuewen Song, Anish A. Kanhai, Ioan-Andrei Iliuta, Andrea Bozovic, Gregory R. Steinberg, Dorien J.M. Peters, York Pei
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2019-09-01
Saila:EBioMedicine
Sarrera elektronikoa:http://www.sciencedirect.com/science/article/pii/S235239641930564X
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