Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB

AcrAB-TolC and their homologs are major multidrug efflux systems in Gram-negative bacteria. The inner membrane component AcrB functions as a trimer. Replacement of Pro223 by Gly in AcrB decreases the trimer stability and drastically reduces the drug efflux activity. The goal of this study is to iden...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zhaoshuai eWang, Meng eZhong, Wei eLu, Qian eChai, Yinan eWei
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Frontiers Media S.A. 2015-01-01
श्रृंखला:Frontiers in Microbiology
विषय:
Oligomerization
efflux pump
membrane transporter
RND
protein thermal stability
ऑनलाइन पहुंच:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00004/full
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन