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Repressive mutations restore function-loss caused by the disruption of trimerization in Escherichia coli multidrug transporter AcrB
AcrAB-TolC and their homologs are major multidrug efflux systems in Gram-negative bacteria. The inner membrane component AcrB functions as a trimer. Replacement of Pro223 by Gly in AcrB decreases the trimer stability and drastically reduces the drug efflux activity. The goal of this study is to iden...
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| Publicado no: | Front Microbiol |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4303003/ https://ncbi.nlm.nih.gov/pubmed/25657644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2015.00004 |
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