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Functional Relevance of AcrB Trimerization in Pump Assembly and Substrate Binding
AcrB is a multidrug transporter in the inner membrane of Escherichia coli. It is an obligate homotrimer and forms a tripartite efflux complex with AcrA and TolC. AcrB is the engine of the efflux machinery and determines substrate specificity. Active efflux depends on several functional features incl...
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Main Authors: | , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
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Public Library of Science
2014
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Teme: | |
Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3925222/ https://ncbi.nlm.nih.gov/pubmed/24551234 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0089143 |
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