Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair.

Ku70 and Ku80 form a heterodimer called Ku that forms a holoenzyme with DNA dependent-protein kinase catalytic subunit (DNA-PKCS) to repair DNA double strand breaks (DSBs) through the nonhomologous end joining (NHEJ) pathway. As expected mutating these genes in mice caused a similar DSB repair-defec...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Yong Jun Choi, Han Li, Mi Young Son, Xiao-Hong Wang, Jamie L Fornsaglio, Robert W Sobol, Moonsook Lee, Jan Vijg, Sandra Imholz, Martijn E T Dollé, Harry van Steeg, Erwin Reiling, Paul Hasty
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science (PLoS) 2014-01-01
Edice:PLoS ONE
On-line přístup:http://europepmc.org/articles/PMC3900520?pdf=render
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky