Oral high dose vitamin B12 decreases renal superoxide and post-ischemia/reperfusion injury in mice

Renal ischemia/reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), a potentially fatal syndrome characterized by a rapid decline in kidney function. Excess production of superoxide contributes to the injury. We hypothesized that oral administration of a high dose of vitamin B12...

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Detalhes bibliográficos
Main Authors: Feng Li, Edward M. Bahnson, Jennifer Wilder, Robin Siletzky, John Hagaman, Volker Nickekeit, Sylvia Hiller, Azraa Ayesha, Lanfei Feng, Jerrold S. Levine, Nobuyuki Takahashi, Nobuyo Maeda-Smithies
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020-05-01
Colecção:Redox Biology
Assuntos:
Cyanocobalamin
Ischemia/reperfusion injury
Superoxide dismutase mimetic
Mouse proximal tubular cells
Inflammation
Fibrosis
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2213231720301282
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