Oral high dose vitamin B12 decreases renal superoxide and post-ischemia/reperfusion injury in mice

Renal ischemia/reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), a potentially fatal syndrome characterized by a rapid decline in kidney function. Excess production of superoxide contributes to the injury. We hypothesized that oral administration of a high dose of vitamin B12...

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Autori principali: Feng Li, Edward M. Bahnson, Jennifer Wilder, Robin Siletzky, John Hagaman, Volker Nickekeit, Sylvia Hiller, Azraa Ayesha, Lanfei Feng, Jerrold S. Levine, Nobuyuki Takahashi, Nobuyo Maeda-Smithies
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2020-05-01
Serie:Redox Biology
Soggetti:
Cyanocobalamin
Ischemia/reperfusion injury
Superoxide dismutase mimetic
Mouse proximal tubular cells
Inflammation
Fibrosis
Accesso online:http://www.sciencedirect.com/science/article/pii/S2213231720301282
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