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Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3

<p>Abstract</p> <p>We have obtained the 1.7 Å crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in complex with the bro...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Elder John H, Torbett Bruce E, Tam Karen, Lin Ying-Chuan, Heaslet Holly, Stout C David
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2007-01-01
Cyfres:Retrovirology
Mynediad Ar-lein:http://www.retrovirology.com/content/4/1/1
Tagiau: Ychwanegu Tag
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