Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3

<p>Abstract</p> <p>We have obtained the 1.7 Å crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in complex with the bro...

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Hlavní autoři: Elder John H, Torbett Bruce E, Tam Karen, Lin Ying-Chuan, Heaslet Holly, Stout C David
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2007-01-01
Edice:Retrovirology
On-line přístup:http://www.retrovirology.com/content/4/1/1
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