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Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3

<p>Abstract</p> <p>We have obtained the 1.7 Å crystal structure of FIV protease (PR) in which 12 critical residues around the active site have been substituted with the structurally equivalent residues of HIV PR (12X FIV PR). The chimeric PR was crystallized in complex with the bro...

詳細記述

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書誌詳細
主要な著者: Elder John H, Torbett Bruce E, Tam Karen, Lin Ying-Chuan, Heaslet Holly, Stout C David
フォーマット: Artigo
言語:Inglês
出版事項: BMC 2007-01-01
シリーズ:Retrovirology
オンライン・アクセス:http://www.retrovirology.com/content/4/1/1
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