The MDM2 inhibitor CGM097 combined with the BET inhibitor OTX015 induces cell death and inhibits tumor growth in models of neuroblastoma

Abstract Background Neuroblastoma (NB) is the most common extracranial solid tumor in infants and children, with amplification of the oncogene MYCN being a hallmark of high‐risk disease and poor prognosis. Although less frequent, overexpression of MYC is similarly an indicator of poor prognosis. Mos...

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Autori principali: Tyler Maser, Joseph Zagorski, Shannon Kelly, Anna Ostrander, Austin Goodyke, Abhinav Nagulapally, Jeffrey Bond, Yeonhee Park, Giselle Saulnier Sholler
Natura: Artigo
Lingua:Inglês
Pubblicazione: Wiley 2020-11-01
Serie:Cancer Medicine
Soggetti:
BET
MDM2
MYC
MYCN
neuroblastoma
p53
Accesso online:https://doi.org/10.1002/cam4.3407
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