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Expression of N-Acetylgalactosamine 4-Sulfate 6-O-Sulfotransferase Involved in Chondroitin Sulfate Synthesis Is Responsible for Pulmonary Metastasis

Chondroitin sulfate (CS) containing E-disaccharide units, glucuronic acid-N-acetylgalactosamine(4, 6-O-disulfate), at surfaces of tumor cells plays a key role in tumor metastasis. However, the molecular mechanism of the metastasis involving the CS chain-containing E-units is not fully understood. In...

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Hlavní autoři: Shuji Mizumoto, Moto Watanabe, Shuhei Yamada, Kazuyuki Sugahara
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Limited 2013-01-01
Edice:BioMed Research International
On-line přístup:http://dx.doi.org/10.1155/2013/656319
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