A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas

Gain-of-function Notch mutations are recurrent in mature small B cell lymphomas such as mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL), but the Notch target genes that contribute to B cell oncogenesis are largely unknown. We performed integrative analysis of Notch-regulated transc...

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Main Authors: Russell J.H. Ryan, Jelena Petrovic, Dylan M. Rausch, Yeqiao Zhou, Caleb A. Lareau, Michael J. Kluk, Amanda L. Christie, Winston Y. Lee, Daniel R. Tarjan, Bingqian Guo, Laura K.H. Donohue, Shawn M. Gillespie, Valentina Nardi, Ephraim P. Hochberg, Stephen C. Blacklow, David M. Weinstock, Robert B. Faryabi, Bradley E. Bernstein, Jon C. Aster, Warren S. Pear
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2017-10-01
Colecção:Cell Reports
Assuntos:
mantle cell lymphoma
chronic lymphocytic leukemia
lymphoma
Notch signaling
MYC
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124717313712
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