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Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer
Clinical evidences have demonstrated limited efficacy of HER2-targeted therapies in patients with gastric cancer (GC). Here the authors show that survival benefit to anti-HER2 antibody Trastuzumab is reduced in GC patients with high levels of the caveolin-1 and that, in preclinical cancer models, an...
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| Main Authors: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2022-05-01
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| Colecção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-022-30142-9 |
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