HDAC Inhibition with Valproate Improves Direct Cytotoxicity of Monocytes against Mesothelioma Tumor Cells

The composition of the tumor microenvironment (TME) mediates the outcome of chemo- and immunotherapies in malignant pleural mesothelioma (MPM). Tumor-associated macrophages (TAMs) and monocyte myeloid-derived immunosuppressive cells (M-MDSCs) constitute a major fraction of the TME. As central cells...

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Detalhes bibliográficos
Main Authors: Clotilde Hoyos, Alexis Fontaine, Jean-Rock Jacques, Vincent Heinen, Renaud Louis, Bernard Duysinx, Arnaud Scherpereel, Eric Wasielewski, Majeed Jamakhani, Malik Hamaidia, Luc Willems
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2022-04-01
Colecção:Cancers
Assuntos:
pleural mesothelioma
monocyte
macrophage
tumor microenvironment
histone deacetylase
valproate
Acesso em linha:https://www.mdpi.com/2072-6694/14/9/2164
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