Involvement of HDAC1 and HDAC3 in the Pathology of Polyglutamine Disorders: Therapeutic Implications for Selective HDAC1/HDAC3 Inhibitors

Histone deacetylases (HDACs) enzymes, which affect the acetylation status of histones and other important cellular proteins, have been recognized as potentially useful therapeutic targets for a broad range of human disorders. Emerging studies have demonstrated that different types of HDAC inhibitors...

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Autor principal: Elizabeth A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2014-05-01
Colecção:Pharmaceuticals
Assuntos:
histone deacetylase (HDAC)
HDAC1
HDAC3
subtype
selective
neurodegenerative
polyglutamine
histone
chromatin
mechanism
Acesso em linha:http://www.mdpi.com/1424-8247/7/6/634
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