Chemoresistance to Valproate Treatment of Bovine Leukemia Virus-Infected Sheep; Identification of Improved HDAC Inhibitors

We previously proved that a histone deacetylase inhibitor (valproate, VPA) decreases the number of leukemic cells in bovine leukemia virus (BLV)-infected sheep. Here, we characterize the mechanisms initiated upon interruption of treatment. We observed that VPA treatment is followed by a decrease of...

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Detalhes bibliográficos
Publicado no:Pathogens
Main Authors: Gillet, Nicolas, Vandermeers, Fabian, de Brogniez, Alix, Florins, Arnaud, Nigro, Annamaria, François, Carole, Bouzar, Amel-Baya, Verlaeten, Olivier, Stern, Eric, Lambert, Didier M., Wouters, Johan, Willems, Luc
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4235689/
https://ncbi.nlm.nih.gov/pubmed/25436765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens1020065
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