A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children. Despite intensive research in recent decades the prognosis for patients with metastatic or relapsed diseases has hardly improved. New therapeutic concepts in anti-tumor therapy aim to modulate the patient’s immune system t...

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Main Authors: Juliane Wagner, Viktoria Pfannenstiel, Anja Waldmann, Judith W. J. Bergs, Boris Brill, Sabine Huenecke, Thomas Klingebiel, Franz Rödel, Christian J. Buchholz, Winfried S. Wels, Peter Bader, Evelyn Ullrich
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017-06-01
Colecção:Frontiers in Immunology
Assuntos:
natural killer cells
radiotherapy
rhabdomyosarcoma
RH30 cells
RD cells
interleukin-15
Acesso em linha:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00676/full
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