Small Molecule Inhibitor Adjuvant Surfactant Therapy Attenuates Ventilator- and Hyperoxia-Induced Lung Injury in Preterm Rabbits

BackgroundInvasive mechanical ventilation (IMV) has become one of the mainstays of therapy in NICUs worldwide, as a result of which premature babies with extremely low birth weight have been able to survive. Although lifesaving, IMV can result in lung inflammation and injury. Surfactant therapy is c...

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Main Authors: Pragnya Das, Tore Curstedt, Beamon Agarwal, Varsha M. Prahaladan, John Ramirez, Shreya Bhandari, Mansoor A. Syed, Fabrizio Salomone, Costanza Casiraghi, Nicola Pelizzi, Vineet Bhandari
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020-04-01
Colecção:Frontiers in Physiology
Assuntos:
surfactant
mechanical ventilation
Ang2 siRNA
CHOP siRNA
miR34a inhibitor
preterm rabbit
Acesso em linha:https://www.frontiersin.org/article/10.3389/fphys.2020.00266/full
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