A tetravalent virus-like particle vaccine designed to display domain III of dengue envelope proteins induces multi-serotype neutralizing antibodies in mice and macaques which confer protection against antibody dependent enhancement in AG129 mice.

Dengue is one of the fastest spreading vector-borne diseases, caused by four antigenically distinct dengue viruses (DENVs). Antibodies against DENVs are responsible for both protection as well as pathogenesis. A vaccine that is safe for and efficacious in all people irrespective of their age and dom...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Hoofdauteurs: Viswanathan Ramasamy, Upasana Arora, Rahul Shukla, Ankur Poddar, Rajgokul K Shanmugam, Laura J White, Melissa M Mattocks, Rajendra Raut, Ashiya Perween, Poornima Tyagi, Aravinda M de Silva, Siddhartha K Bhaumik, Murali Krishna Kaja, François Villinger, Rafi Ahmed, Robert E Johnston, Sathyamangalam Swaminathan, Navin Khanna
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science (PLoS) 2018-01-01
Reeks:PLoS Neglected Tropical Diseases
Online toegang:http://europepmc.org/articles/PMC5774828?pdf=render
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items