Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance

Abstract Background Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that regulate epigenetic information in the germline and its transmission to o...

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Bibliographic Details
Main Authors: Jessica M. Stringer, Samuel C. Forster, Zhipeng Qu, Lexie Prokopuk, Moira K. O’Bryan, David K. Gardner, Stefan J. White, David Adelson, Patrick S. Western
Format: Artigo
Language:Inglês
Published: BMC 2018-09-01
Series:BMC Biology
Subjects:
Germline
Epigenetic reprogramming
PRC2
H3K27me3
Paternal inheritance
Fertility
Online Access:http://link.springer.com/article/10.1186/s12915-018-0569-5
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