Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance

Abstract Background Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that regulate epigenetic information in the germline and its transmission to o...

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Autori principali: Jessica M. Stringer, Samuel C. Forster, Zhipeng Qu, Lexie Prokopuk, Moira K. O’Bryan, David K. Gardner, Stefan J. White, David Adelson, Patrick S. Western
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2018-09-01
Serie:BMC Biology
Soggetti:
Germline
Epigenetic reprogramming
PRC2
H3K27me3
Paternal inheritance
Fertility
Accesso online:http://link.springer.com/article/10.1186/s12915-018-0569-5
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