Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance

Abstract Background Defining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for understanding disease heredity. Currently, the molecular pathways that regulate epigenetic information in the germline and its transmission to o...

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Autores principales: Jessica M. Stringer, Samuel C. Forster, Zhipeng Qu, Lexie Prokopuk, Moira K. O’Bryan, David K. Gardner, Stefan J. White, David Adelson, Patrick S. Western
Formato: Artigo
Lenguaje:Inglês
Publicado: BMC 2018-09-01
Colección:BMC Biology
Materias:
Germline
Epigenetic reprogramming
PRC2
H3K27me3
Paternal inheritance
Fertility
Acceso en línea:http://link.springer.com/article/10.1186/s12915-018-0569-5
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