Identifying problematic drugs based on the characteristics of their targets

Identifying promising compounds during the early stages of drug development is a major challenge for both academia and the pharmaceutical industry. The difficulties are even more pronounced when we consider multi-target pharmacology, where the compounds often target more than one protein, or multipl...

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Detalhes bibliográficos
Main Authors: Tiago Jose eDa Silva Lopes, Jason Edward Shoemaker, Yukiko eMatsuoka, Hiroaki eKitano, Yoshihiro eKawaoka
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015-09-01
Colecção:Frontiers in Pharmacology
Assuntos:
machine learning
drug safety
protein networks
Target validation
supervised learning
multi-target drugs
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fphar.2015.00186/full
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