Lysine Acetylation Reshapes the Downstream Signaling Landscape of Vav1 in Lymphocytes

Vav1 works both as a catalytic Rho GTPase activator and an adaptor molecule. These functions, which are critical for T cell development and antigenic responses, are tyrosine phosphorylation-dependent. However, it is not known whether other posttranslational modifications can contribute to the regula...

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Main Authors: Sonia Rodríguez-Fdez, Lucía Fernández-Nevado, L. Francisco Lorenzo-Martín, Xosé R. Bustelo
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-03-01
Serier:Cells
Fag:
vav
guanosine nucleotide exchange factor
rac1
rho
jnk
nfat
t cell receptor
acetylation
tyrosine phosphorylation
adaptor
Online adgang:https://www.mdpi.com/2073-4409/9/3/609
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